Список публикаций Лаборатории синтеза антибиотиков, преодолевающих резистентность (САПР)

1. T.S. Shkuratova, D.V. Andreeva, A.S. Tikhomirov, A.E. Shchekotikhin, Gramicidin S analogues as a pathway to overcome antimicrobial resistance, Future Medicinal Chemistry 2026, https://doi.org/10.1080/17568919.2026.2736285 

   

2. T.S. Shkuratova, K.V. Rychev, V.G. Grigorenko, I.P. Andreeva, N.E. Grammatikova, A.S. Tikhomirov, A.M. Egorov, Andrey E. Shchekotikhin, Expansion of Pyrrole-2-carboxylic Acid-Based Metallo-β-Lactamase Inhibitors: C4 Functionalization Drives Dual NDM/VIM Inhibition, Bioorganic Chemistry 2026, 181, 110276, 

   

3. C.-Y. Chen, A.S. Tikhomirov, Y.-F. Liou, C.-W. Chen, S.-H. Chiu, A. Islam, A.E. Shchekotikhin, P.J. Chueh. p53-Dependent ENOX2 Downregulation Mediates the Apoptotic Responses to Heteroarene-Fused Anthraquinones in Colon Cancer Cells. Biomolecules 2026, 16(7), 1043; https://doi.org/10.3390/biom16071043 

   

4. G.I. Buravchenko, A.S. Tikhomirov, A.E. Shchekotikhin, Revisiting heliomycin: Chemistry, biological activity, and perspectives for drug development, European Journal of Medicinal Chemistry 2026, 316, 119060, 10.1016/j.ejmech.2026.119060 

   

5. V. Sapozhnikova, E. Knizhnik, D. Shirokov, Y. Khodarovich, J. Khomyakova, M. Bogomiakova, A. Tikhomirov, A. Shchekotikhin, A. Varizhuk, V. Tsvetkov. Intercalated Motifs Contribute to Transcription Regulation in an Acidosis Model, Biomolecules 2026, 16(7), 1038; https://doi.org/10.3390/biom16071038 

   

6. A.S. Tikhomirov, V.G. Grigorenko, G.V. Presnova, M.Yu. Rubtsova, T.S. Shkuratova, P. Tiuleanu, A.M. Egorov, A.E. Shchekotikhin. Rational Design and Screening of Inhibitors Using Recombinant Metallo-β-Lactamases. Russian Journal of Bioorganic Chemistry 2026, 52:137, https://doi.org/10.1134/S1068162026602818

   

7. D.V. Andreeva, V.B. Tsvetkov, V.A. Litvinova, T.S. Vedekhina, V.A. Sapozhnikova, G.V. Zatonsky, A.M. Varizhuk, A.S. Tikhomirov, A.E. Shchekotikhin, Cationic side chain-functionalized heteroarenefused anthraquinones as selective G-quadruplex stabilizers, RSC Medicinal Chemistry 2026, 17, 3844–3859, DOI:10.1039/d6md00404k. 

   

8. A.S. Tikhomirov, L.G. Dezhenkova, Y.L. Volodina, D.N. Kaluzhny, D. Schols,  A.E. Shchekotikhin, Synthesis and evaluation of new 2-substituted anthra[2,3-b]furan-5,10-diones: tumor cell apoptosis through DNA binding and topoisomerases inhibition. Bioorganic & Medicinal Chemistry 2026, 137, 118615, https://doi.org/10.1016/j.bmc.2026.118615 

   

9. E.I. Moiseenko, L.N. Lysenkova, A.S. Gostev, N.E. Grammatikova, E.B. Isakova, E.R. Pereverzeva, G.V. Zatonsky, G.Batta, R.P. Erdei, A.S. Tikhomirov, A.E. Shchekotikhin, N-(ω-Guanidinoalkyl)amides of Eremomycin: New Type of Glycopeptides with High Potency against Planktonic Forms and Biofilms of Resistant Bacteria, ACS Infectious Diseases 2026, 12, 4, 1338–1349, https://doi.org/10.1021/acsinfecdis.5c01004 

   

10. I.A. Volynkina, M.O. Bortyazh, C. Chen, A.G. Tereshchenkov, A.O. Karakchieva, D.A. Lukianov, E.S. Komarova, A.E. Tupikin, D.A. Skvortsov, A.N. Tevyashova, A.S. Tikhomirov, V.N. Tashlitsky, M.R. Kabilov, A.E. Shchekotikhin, O.A. Dontsova, Y.S. Polikanov, P.V. Sergiev, Benzoxaborole-modified azithromycins inhibit translation without inducing ermC expression. Antimicrobial Agents and Chemotherapy 2026, 0:e01539-25, https://doi.org/10.1128/aac.01539-25 

    

11. V.A. Alekhin, S.F. Nazarova, A.S. Tikhomirov, V.V. Pavlov, O.V. Moiseeva, V.I. Gordeliy, N.S. Ilyinsky, Enhancement of Lysosomal Biogenesis in the HCT116 Cells Treated with Doxorubicin under Normoxic Conditions, Biochemistry Moscow2026, 91, 199–215. https://doi.org/10.1134/S0006297925601947 

    

12. D.I. Salnikova, A.S. Tikhomirov, A.L. Mikhaylova, A.I. Khamidullina, A.E. Shchekotikhin, A.M. Scherbakov, Application of a New Heliomycin Derivative Against Breast Cancer Under Normoxia and Hypoxia. Engineering Proceedings 2026, 124(1), 70. https://doi.org/10.3390/engproc2026124070 

    

13. M.M. Martynov, I.A. Volynkina, N.E. Grammatikova, M.A. Kryakvin, N.D. Dadaev, A.O. Karakchieva, O.A. Dontsova, G.V. Zatonsky, A.S. Tikhomirov, A.E. Shchekotikhin. 4″-Modified azithromycin derivatives bearing nitrogen-containing heterocycles with dual inhibitory activity. Bioorganic Chemistry 2026, 169, 109396. doi:10.1016/j.bioorg.2025.109396.

    

14. T.S. Shkuratova, K.V. Rychev, V.G. Grigorenko, I.P. Andreeva, N.E. Grammatikova, A.S. Tikhomirov, A.M. Egorov, A.E. Shchekotikhin. Rational Design of 1H-pyrrole-2-carboxylic Acid Inhibitors of NDM-1 Metallo-β-lactamase Restoring β-Lactam Efficacy Against Resistant Enterobacterales. European Journal of Medicinal Chemistry 2026, 302(3), 118376; https://doi.org/10.1016/j.ejmech.2025.118376

    

15. M.A. Burkin, V.A. Litvinova, A.S. Tikhomirov, E.Y. Katarzhnova, I.A. Galvidis. Effect of Carrier Protein Size on Hapten Immunogenicity and Antibody Affinity in Mice. Bioconjugate Chemistry 2026, 37, 1, 216–224 https://doi.org/10.1021/acs.bioconjchem.5c00606.

    

16. K.S. Shapovalova, G.V. Zatonsky, E.A. Razumova, N.D. Dagaev, D.A. Lukianov, N.E. Grammatikova, A.S. Tikhomirov, A.E. Shchekotikhin. Design, Synthesis, and Biological Evaluation of 6″-Modified Apramycin Derivatives to Overcome Aminoglycoside Resistance. Pharmaceutics 2025, 17, 1583; https://doi.org/10.3390/pharmaceutics17121583

    

17. A.S. Tikhomirov, S.E. Solov’eva, T.S. Shkuratova, N.M. Malyutina, D.V. Andreeva, G.V. Zatonsky, N.E. Grammatikova, A.E. Shchekotikhin. Isolation of Cyclic Decapeptide Antibiotics Related to Gramicidin S. Natural Product Research 2025, 1–5; https://doi.org/10.1080/14786419.2025.2568953 

    

18. S.N. Lavrenov, A.Yu. Simonov, A.A. Panov, S.E. Solovieva, A.B. Mantsyzov, A.V. Churakov, A.S. Trenin, I.B. Levshin. Azole Homodimers as Promising Antifungal Agents: Synthesis, Biological Activity Evaluation and Molecular Modeling. Current Pharmaceutical Design 2025, 32(37), 8479–8493; https://doi.org/10.2174/0109298673351661241219053546 

    

19. C.-Y. Hsieh, Y.-F. Liou, Y.-T. Shih, A.S. Tikhomirov, A.E. Shchekotikhin, P.J. Chueh. Olivomycin A Targets Epithelial–Mesenchymal Transition, Apoptosis, and Mitochondrial Quality Control in Renal Cancer Cells. Antioxidants 2025, 14, 1348; https://doi.org/10.3390/antiox14111348

    

20. D.V. Khabarov, V.A. Litvinova, L.G. Dezhenkova, D.N. Kaluzhny, A.S. Tikhomirov, AE Shchekotikhin. Discovery of cytotoxic indolo[1, 2-c]quinazoline derivatives through scaffold-based design. Beilstein Journal of Organic Chemistry 2025, 21(1), 2062-2071; https://doi.org/10.3762/bjoc.21.161.

    

21. T.S. Shkuratova, D.V. Andreeva, A.S. Tikhomirov, A.E. Shchekotikhin. Analogues of gramicidin S: A promising direction for future antibacterial drug development? European Journal of Medicinal Chemistry, 2025, 297, 117955; https://doi.org/10.1016/j.ejmech.2025.117955. 

    

22. Панов А.А. Квантовохимическое исследование энергий изомерных производных малеимида и итаконимида. Журнал физической химии, 2025, Т. 99, № 4, 605-610; https://doi.org/10.31857/S0044453725040098 [Panov A.A. Quantum chemical study of the energies of isomeric maleimide and itaconimide derivatives. Russian Journal of Physical Chemistry, 2025, Т. 99, № 3, 522-527; https://doi.org/10.31857/S0044453725040098] 

    

23. Simonov A.Yu., Panov A.A., Churakov A.V., Polshakov V.I., Levshin I.B. Oxirane-driven cascade transformations of 5-arylidene-thiazolidine-2,4-diones. Asian Journal of Organic Chemistry, 2025, Т. 14, № 3; https://doi.org/10.1002/ajoc.202400645 

    

24. M.M. Martynov, N.E. Grammatikova, G.V. Zatonsky, S.E. Solovieva, A.S. Tikhomirov, E.N. Bychkova, A.E. Shchekotikhin, Synthesis and Estimation of the Antibacterial Potency of a Series of Azithromycin-Siderophore Conjugates. Current Organic Chemistry, 2025; https://doi.org/10.2174/0113852728404096250908065829 

    

25. K.S. Shapovalova, G.V. Zatonsky, E.A. Razumova, D.A. Ipatova, D.A. Lukianov, P.V. Sergiev, N.E. Grammatikova, A.S. Tikhomirov, A.E. Shchekotikhin. Synthesis and antibacterial activity of new 6″-modified tobramycin derivatives, Antibiotics 2024, 13(12), 1191; https://doi.org/10.3390/antibiotics13121191

    

26. T.S. Shkuratova, V.G. Grigorenko, I.P. Andreeva, V.A. Litvinova, N.E. Grammatikova, A.S. Tikhomirov, A.M. Egorov, A.E. Shchekotikhin. New derivatives of dipicolinic acid as metallo-β-lactamase NDM-1 inhibitors. Medicinal Chemistry Research, 2024, https://doi.org/10.1007/s00044-024-03330-z

    

27. M.A. Burkin, A.S. Tikhomirov, Y.A. Surovoy, I.A. Galvidis. Hapten synthesis, antibody generation, and immunoassay development for linezolid therapeutic monitoring, Analytical Chemistry 2024, 96, 44, 17859–17867, https://doi.org/10.1021/acs.analchem.4c04537

    

28. O. Omelchuk, E. Bychkova, S. Efimova, N. Grammatikova, G. Zatonsky, L. Dezhenkova, S. Solovieva, O. Ostroumova, A. Tevyashova, A. Shchekotikhin, Mono-N-alkylation of Amphotericin B and Nystatin A1 and Its Amides: Effect on the In Vitro Activity, Cytotoxicity and Permeabilization of Model Membranes, Antibiotics 2024, 13(12), 1177, https://doi.org/10.3390/antibiotics13121177

    

29. V.A. Litvinova, V.B. Tsvetkov, Y.L. Volodina, L.G. Dezhenkova, A.A. Markova, M.T. Nguyen,  A.S. Tikhomirov, A.E. Shchekotikhin, Naphthoindole-2-carboxamides as a lipophilic chemotype of hetarene-anthraquinones potent against P-gp resistant tumor cells, European Journal of Medicinal Chemistry, 2025, 281, 117013, https://doi.org/10.1016/j.ejmech.2024.117013

    

30. I.B. Levshin, A.Y. Simonov, A.A. Panov, N.E. Grammatikova, A.I. Alexandrov, E.S.M.O. Ghazy, V.A. Ivlev, M.O. Agaphonov, A.B. Mantsyzov, V.I. Polshakov, Synthesis and Biological Evaluation of a Series of New Hybrid Amide Derivatives of Triazole and Thiazolidine-2,4-dione, Pharmaceuticals, 2024, 17, 723; https://doi.org/10.3390
    /ph17060723

    

31. A.A. Panov, New Methods of Synthesis of Fused Maleimides, Russian Journal of Organic Chemistry, 2024, 60, 553–567; https://doi.org/10.1134/S1070428024040018
     

    

32. D.V. Andreeva, A.S. Tikhomirov, A.E. Shchekotikhin, Synthesis and antiproliferative activity of thiazole-fused anthraquinones, Organic & Biomolecular Chemistry, 2024, in press; https://doi.org/10.1039/D4OB01284D 
     

    

33. V.N. Charushin, E.V. Verbitskiy, O.N. Chupakhin, D.V. Vorobyeva, P.S. Gribanov, S.N. Osipov, A.V. Ivanov, S.V. Martynovskaya, E.F. Sagitova, V.D. Dyachenko, I.V. Dyachenko, S.G. Krivokolysko, V.V. Dotsenko, A.V. Aksenov, D.A. Aksenov, N.A. Aksenov, A.A. Larin, L.L. Fershtat, V.M. Muzalevskiy, V.G. Nenajdenko, A.V. Gulevskaya, A.F. Pozharskii, E.A. Filatova, K.V. Belyaeva, B.A. Trofimov, I.A. Balova, N.A. Danilkina, A.I. Govdi, A.S. Tikhomirov, A.E. Shchekotikhin, M.S. Novikov, N.V. Rostovskii, A.F. Khlebnikov, Yu.N. Klimochkin, M.V. Leonova, I.M. Tkachenko, V.A. Mamedov, V.L. Mamedova, N.A. Zhukova, V.E. Semenov, O.G. Sinyashin, O.V. Borshchev, Yu.N. Luponosov, S.A. Ponomarenko, A.S. Fisyuk, A.S. Kostyuchenko, V.G. Ilkin, T.V. Beryozkina, V.A. Bakulev, A.S. Gazizov, A.A. Zagidullin, A.A. Karasik, M.E. Kukushkin, E.K. Beloglazkina, N.E. Golantsov, A.A. Festa, L.G. Voskresensky, V.S. Moshkin, E.M. Buev, V.Ya. Sosnovskikh, I.A. Mironova, P.S. Postnikov, V.V. Zhdankin, M.S. Yusubov, I.A. Yaremenko, V.A. Vil', I.B. Krylov, A.O. Terent'ev, Yu.G. Gorbunova, A.G. Martynov, A.Yu. Tsivadze, P.A. Stuzhin, S.S. Ivanova, O.I. Koifman, O.N. Burov, M.E. Kletskii, S.V. Kurbatov, O.I. Yarovaya, K.P. Volcho, N.F. Salakhutdinov, M.A. Panova, Ya.V. Burgart, V.I. Saloutin, A.R. Sitdikova, E.S. Shchegravina, A.Yu. Fedorov, The chemistry of heterocycles in the 21st century, Russian Chemical Reviews, 2024, 93 (7), RCR5125; https://doi.org/10.59761/RCR5125
     

    

34. D.V. Andreeva, T.S. Vedekhina, A.S. Gostev, L.G. Dezhenkova, Y.L. Volodina, A.A. Markova, M.T. Nguyen, O.M. Ivanova, V.A. Dolgusheva, A.M. Varizhuk, A.S. Tikhomirov, A.E. Shchekotikhin, Thiadiazole-, selenadiazole- and triazole-fused anthraquinones as G-quadruplex targeting anticancer compounds, European Journal of Medicinal Chemistry, 2024, 268, 116222; https://doi.org/10.1016/j.ejmech.2024.116222

    

35. I.A. Volynkina, E.N. Bychkova, A.O. Karakchieva, A.S. Tikhomirov, G.V. Zatonsky, S.E. Solovieva, M.M. Martynov, N.E. Grammatikova, A.G. Tereshchenkov, A. Paleskava, A.L. Konevega, P.V. Sergiev, O.A. Dontsova, I.A. Osterman, A.E. Shchekotikhin, A.N. Tevyashova, Hybrid Molecules of Azithromycin with Chloramphenicol and Metronidazole: Synthesis and Study of Antibacterial Properties, Pharmaceuticals, 2024, 17 (2), 187; https://doi.org/10.3390/ph17020187

    

36. V.A.Litvinova, A.S.Tikhomirov, A.E.Shchekotikhin, Methods for functionalization of anthraquinones, Russian Chemical Reviews, 2024, 93, RCR5141, DOI: https://doi.org/10.59761/RCR5141

    

37. A.S. Tikhomirov, Y.B. Sinkevich, L.G. Dezhenkova, D.N. Kaluzhny, N.S. Ilyinsky, V.I. Borshchevskiy, D. Schols, A.E. Shchekotikhin, Synthesis and antitumor activity of cyclopentane-fused anthraquinone derivatives, European Journal of Medicinal Chemistry, 2024, 265, 116103, https://doi.org/10.1016/j.ejmech.2023.116103

38. M.I. Treshchalin, V.A. Polozkova, E.I. Moiseenko, A.E. Shchekotikhin, S.A. Dovzhenko, M.B. Kobrin, E.R. Pereverzeva, Experimental Evaluation of the Hypersensitivity Reactions of a New Glycopeptide Antibiotic Flavancin in Animal Models, Pharmaceuticals, 2023, 16(11), 1569; https://doi.org/10.3390/ph16111569

     

39. V.A. Litvinova, A.S. Gostev, A.S. Tikhomirov, A.E. Shchekotikhin, New heteroarene-fused anthraquinones: Synthesis and PyBOP-mediated amination, Tetrahedron, 2023, 149, 4, 133722, https://doi.org/https://doi.org/10.1016/j.tet.2023.133722

     

40. A. Islam, X.C. Chen, C.-W. Weng, C.-Y. Chen, C.-W. Wang, M.-K. Chen, A.S. Tikhomirov, A.E. Shchekotikhin, P.J. Chueh, Water-soluble 4-(dimethylaminomethyl)heliomycin exerts greater antitumor effects than parental heliomycin by targeting the tNOX-SIRT1 axis and apoptosis in oral cancer cells, eLife, 2023, https://doi.org/10.7554/eLife.87873.1

     

41. В.А. Литвинова, А.С. Тихомиров, Методы синтеза 1,3-оксазолидин-2-онов, Методы синтеза 1,3-оксазолидин-2-онов, Химия гетероциклических соединений, 2023, 59(11/12), 733-735

     

42. K. Shapovalova, G. Zatonsky, N. Grammatikova, I. Osterman, E. Razumova, A. Shchekotikhin, A. Tevyashova, Synthesis of 6”-Modified Kanamycin A Derivatives and Evaluation of Their Antibacterial Properties. Pharmaceutics, 2023, 15, 1177. https://doi.org/10.3390/pharmaceutics15041177

     

43. A.A. Panov, Quantum-Chemical Study of Keto-Enol Equilibrium and Global Electrophilicity of Hydroxymaleimide Derivatives. Doklady Physical Chemistry, 2023, 508, 28–32, https://doi.org/10.1134/S001250162360002X

     

44. Levshin I.B., Simonov A.Y., Lavrenov S.N., Panov A.A., Grammatikova N.E., Alexandrov A.I., Ghazy E.S.M.O., Savin N.A., Gorelkin P.V., Erofeev A.S., Polshakov V.I. Antifungal Thiazolidines: Synthesis and Biological Evaluation of Mycosidine Congeners. Pharmaceuticals, 2022, 15, 5, 563-586. DOI: 10.3390/ph15050563

     

45. Treshchalin M.I., Polozkova V.A., Moiseenko E.I., Treshalina H.M., Shchekotikhin A.E., Pereverzeva E.R. Evaluation of Toxic Properties of New Glycopeptide Flavancin on Rats. Pharmaceuticals, 2022, 15, 661. DOI: 10.3390/ph15060661

     

46. A.N. Tevyashova, S.S. Efimova, A.I. Alexandrov, E.S.M.O. Ghazy, E.N. Bychkova, S.E. Solovieva, G.B. Zatonsky, N.E. Grammatikova, L.G. Dezhenkova, E.R. Pereverzeva, E.B. Isakova, O.S. Ostroumova, O.A. Omelchuk, V.V. Muravieva, M.M. Krotova, T.V. Priputnevich, A.E. Shchekotikhin, Semisynthetic Amides of Polyene Antibiotic Natamycin, ACS Infectious Diseases 2022, 2022, https://doi.org/10.1021/acsinfecdis.2c00237

47. A. Tevyashova, S. Efimova, A. Alexandrov, O. Omelchuk, E. Ghazy, E. Bychkova, G. Zatonsky, N. Grammatikova, L. Dezhenkova, S. Solovieva, O. Ostroumova, A. Shchekotikhin, Semisynthetic Amides of Amphotericin B and Nystatin A1: A Comparative Study of In Vitro Activity/Toxicity Ratio in Relation to Selectivity to Ergosterol Membranes, Antibiotics 2023, 12(1), 151; https://doi.org/10.3390/antibiotics12010151