Список публикаций Лаборатории синтеза антибиотиков, преодолевающих резистентность (САПР)

1. M.M. Martynov, I.A. Volynkina, N.E. Grammatikova, M.A. Kryakvin, N.D. Dadaev, A.O. Karakchieva, O.A. Dontsova, G.V. Zatonsky, A.S. Tikhomirov, A.E. Shchekotikhin. 4″-Modified azithromycin derivatives bearing nitrogen-containing heterocycles with dual inhibitory activity. Bioorganic Chemistry 2026, 169, 109396. doi:10.1016/j.bioorg.2025.109396.

   

2. T.S. Shkuratova, K.V. Rychev, V.G. Grigorenko, I.P. Andreeva, N.E. Grammatikova, A.S. Tikhomirov, A.M. Egorov, A.E. Shchekotikhin. Rational Design of 1H-pyrrole-2-carboxylic Acid Inhibitors of NDM-1 Metallo-β-lactamase Restoring β-Lactam Efficacy Against Resistant Enterobacterales. European Journal of Medicinal Chemistry 2026, 302(3), 118376; https://doi.org/10.1016/j.ejmech.2025.118376

   

3. M.A. Burkin, V.A. Litvinova, A.S. Tikhomirov, E.Y. Katarzhnova, I.A. Galvidis. Effect of Carrier Protein Size on Hapten Immunogenicity and Antibody Affinity in Mice. Bioconjugate Chemistry 2026, 37, 1, 216–224 https://doi.org/10.1021/acs.bioconjchem.5c00606.

   

4. K.S. Shapovalova, G.V. Zatonsky, E.A. Razumova, N.D. Dagaev, D.A. Lukianov, N.E. Grammatikova, A.S. Tikhomirov, A.E. Shchekotikhin. Design, Synthesis, and Biological Evaluation of 6″-Modified Apramycin Derivatives to Overcome Aminoglycoside Resistance. Pharmaceutics 2025, 17, 1583; https://doi.org/10.3390/pharmaceutics17121583

   

5. A.S. Tikhomirov, S.E. Solov’eva, T.S. Shkuratova, N.M. Malyutina, D.V. Andreeva, G.V. Zatonsky, N.E. Grammatikova, A.E. Shchekotikhin. Isolation of Cyclic Decapeptide Antibiotics Related to Gramicidin S. Natural Product Research 2025, 1–5; https://doi.org/10.1080/14786419.2025.2568953 

   

6. S.N. Lavrenov, A.Yu. Simonov, A.A. Panov, S.E. Solovieva, A.B. Mantsyzov, A.V. Churakov, A.S. Trenin, I.B. Levshin. Azole Homodimers as Promising Antifungal Agents: Synthesis, Biological Activity Evaluation and Molecular Modeling. Current Pharmaceutical Design 2025, 32(37), 8479–8493; https://doi.org/10.2174/0109298673351661241219053546 

   

7. C.-Y. Hsieh, Y.-F. Liou, Y.-T. Shih, A.S. Tikhomirov, A.E. Shchekotikhin, P.J. Chueh. Olivomycin A Targets Epithelial–Mesenchymal Transition, Apoptosis, and Mitochondrial Quality Control in Renal Cancer Cells. Antioxidants 2025, 14, 1348; https://doi.org/10.3390/antiox14111348

   

8. D.V. Khabarov, V.A. Litvinova, L.G. Dezhenkova, D.N. Kaluzhny, A.S. Tikhomirov, AE Shchekotikhin. Discovery of cytotoxic indolo[1, 2-c]quinazoline derivatives through scaffold-based design. Beilstein Journal of Organic Chemistry 2025, 21(1), 2062-2071; https://doi.org/10.3762/bjoc.21.161.

   

9. T.S. Shkuratova, D.V. Andreeva, A.S. Tikhomirov, A.E. Shchekotikhin. Analogues of gramicidin S: A promising direction for future antibacterial drug development? European Journal of Medicinal Chemistry, 2025, 297, 117955; https://doi.org/10.1016/j.ejmech.2025.117955. 

   

10. Панов А.А. Квантовохимическое исследование энергий изомерных производных малеимида и итаконимида. Журнал физической химии, 2025, Т. 99, № 4, 605-610; https://doi.org/10.31857/S0044453725040098 [Panov A.A. Quantum chemical study of the energies of isomeric maleimide and itaconimide derivatives. Russian Journal of Physical Chemistry, 2025, Т. 99, № 3, 522-527; https://doi.org/10.31857/S0044453725040098] 

    

11. Simonov A.Yu., Panov A.A., Churakov A.V., Polshakov V.I., Levshin I.B. Oxirane-driven cascade transformations of 5-arylidene-thiazolidine-2,4-diones. Asian Journal of Organic Chemistry, 2025, Т. 14, № 3; https://doi.org/10.1002/ajoc.202400645 

    

12. M.M. Martynov, N.E. Grammatikova, G.V. Zatonsky, S.E. Solovieva, A.S. Tikhomirov, E.N. Bychkova, A.E. Shchekotikhin, Synthesis and Estimation of the Antibacterial Potency of a Series of Azithromycin-Siderophore Conjugates. Current Organic Chemistry, 2025; https://doi.org/10.2174/0113852728404096250908065829 

    

13. K.S. Shapovalova, G.V. Zatonsky, E.A. Razumova, D.A. Ipatova, D.A. Lukianov, P.V. Sergiev, N.E. Grammatikova, A.S. Tikhomirov, A.E. Shchekotikhin. Synthesis and antibacterial activity of new 6″-modified tobramycin derivatives, Antibiotics 2024, 13(12), 1191; https://doi.org/10.3390/antibiotics13121191

    

14. T.S. Shkuratova, V.G. Grigorenko, I.P. Andreeva, V.A. Litvinova, N.E. Grammatikova, A.S. Tikhomirov, A.M. Egorov, A.E. Shchekotikhin. New derivatives of dipicolinic acid as metallo-β-lactamase NDM-1 inhibitors. Medicinal Chemistry Research, 2024, https://doi.org/10.1007/s00044-024-03330-z

    

15. M.A. Burkin, A.S. Tikhomirov, Y.A. Surovoy, I.A. Galvidis. Hapten synthesis, antibody generation, and immunoassay development for linezolid therapeutic monitoring, Analytical Chemistry 2024, 96, 44, 17859–17867, https://doi.org/10.1021/acs.analchem.4c04537

    

16. O. Omelchuk, E. Bychkova, S. Efimova, N. Grammatikova, G. Zatonsky, L. Dezhenkova, S. Solovieva, O. Ostroumova, A. Tevyashova, A. Shchekotikhin, Mono-N-alkylation of Amphotericin B and Nystatin A1 and Its Amides: Effect on the In Vitro Activity, Cytotoxicity and Permeabilization of Model Membranes, Antibiotics 2024, 13(12), 1177, https://doi.org/10.3390/antibiotics13121177

    

17. V.A. Litvinova, V.B. Tsvetkov, Y.L. Volodina, L.G. Dezhenkova, A.A. Markova, M.T. Nguyen,  A.S. Tikhomirov, A.E. Shchekotikhin, Naphthoindole-2-carboxamides as a lipophilic chemotype of hetarene-anthraquinones potent against P-gp resistant tumor cells, European Journal of Medicinal Chemistry, 2025, 281, 117013, https://doi.org/10.1016/j.ejmech.2024.117013

    

18. I.B. Levshin, A.Y. Simonov, A.A. Panov, N.E. Grammatikova, A.I. Alexandrov, E.S.M.O. Ghazy, V.A. Ivlev, M.O. Agaphonov, A.B. Mantsyzov, V.I. Polshakov, Synthesis and Biological Evaluation of a Series of New Hybrid Amide Derivatives of Triazole and Thiazolidine-2,4-dione, Pharmaceuticals, 2024, 17, 723; https://doi.org/10.3390
    /ph17060723

    

19. A.A. Panov, New Methods of Synthesis of Fused Maleimides, Russian Journal of Organic Chemistry, 2024, 60, 553–567; https://doi.org/10.1134/S1070428024040018
     

    

20. D.V. Andreeva, A.S. Tikhomirov, A.E. Shchekotikhin, Synthesis and antiproliferative activity of thiazole-fused anthraquinones, Organic & Biomolecular Chemistry, 2024, in press; https://doi.org/10.1039/D4OB01284D 
     

    

21. V.N. Charushin, E.V. Verbitskiy, O.N. Chupakhin, D.V. Vorobyeva, P.S. Gribanov, S.N. Osipov, A.V. Ivanov, S.V. Martynovskaya, E.F. Sagitova, V.D. Dyachenko, I.V. Dyachenko, S.G. Krivokolysko, V.V. Dotsenko, A.V. Aksenov, D.A. Aksenov, N.A. Aksenov, A.A. Larin, L.L. Fershtat, V.M. Muzalevskiy, V.G. Nenajdenko, A.V. Gulevskaya, A.F. Pozharskii, E.A. Filatova, K.V. Belyaeva, B.A. Trofimov, I.A. Balova, N.A. Danilkina, A.I. Govdi, A.S. Tikhomirov, A.E. Shchekotikhin, M.S. Novikov, N.V. Rostovskii, A.F. Khlebnikov, Yu.N. Klimochkin, M.V. Leonova, I.M. Tkachenko, V.A. Mamedov, V.L. Mamedova, N.A. Zhukova, V.E. Semenov, O.G. Sinyashin, O.V. Borshchev, Yu.N. Luponosov, S.A. Ponomarenko, A.S. Fisyuk, A.S. Kostyuchenko, V.G. Ilkin, T.V. Beryozkina, V.A. Bakulev, A.S. Gazizov, A.A. Zagidullin, A.A. Karasik, M.E. Kukushkin, E.K. Beloglazkina, N.E. Golantsov, A.A. Festa, L.G. Voskresensky, V.S. Moshkin, E.M. Buev, V.Ya. Sosnovskikh, I.A. Mironova, P.S. Postnikov, V.V. Zhdankin, M.S. Yusubov, I.A. Yaremenko, V.A. Vil', I.B. Krylov, A.O. Terent'ev, Yu.G. Gorbunova, A.G. Martynov, A.Yu. Tsivadze, P.A. Stuzhin, S.S. Ivanova, O.I. Koifman, O.N. Burov, M.E. Kletskii, S.V. Kurbatov, O.I. Yarovaya, K.P. Volcho, N.F. Salakhutdinov, M.A. Panova, Ya.V. Burgart, V.I. Saloutin, A.R. Sitdikova, E.S. Shchegravina, A.Yu. Fedorov, The chemistry of heterocycles in the 21st century, Russian Chemical Reviews, 2024, 93 (7), RCR5125; https://doi.org/10.59761/RCR5125
     

    

22. D.V. Andreeva, T.S. Vedekhina, A.S. Gostev, L.G. Dezhenkova, Y.L. Volodina, A.A. Markova, M.T. Nguyen, O.M. Ivanova, V.A. Dolgusheva, A.M. Varizhuk, A.S. Tikhomirov, A.E. Shchekotikhin, Thiadiazole-, selenadiazole- and triazole-fused anthraquinones as G-quadruplex targeting anticancer compounds, European Journal of Medicinal Chemistry, 2024, 268, 116222; https://doi.org/10.1016/j.ejmech.2024.116222

    

23. I.A. Volynkina, E.N. Bychkova, A.O. Karakchieva, A.S. Tikhomirov, G.V. Zatonsky, S.E. Solovieva, M.M. Martynov, N.E. Grammatikova, A.G. Tereshchenkov, A. Paleskava, A.L. Konevega, P.V. Sergiev, O.A. Dontsova, I.A. Osterman, A.E. Shchekotikhin, A.N. Tevyashova, Hybrid Molecules of Azithromycin with Chloramphenicol and Metronidazole: Synthesis and Study of Antibacterial Properties, Pharmaceuticals, 2024, 17 (2), 187; https://doi.org/10.3390/ph17020187

    

24. V.A.Litvinova, A.S.Tikhomirov, A.E.Shchekotikhin, Methods for functionalization of anthraquinones, Russian Chemical Reviews, 2024, 93, RCR5141, DOI: https://doi.org/10.59761/RCR5141

    

25. A.S. Tikhomirov, Y.B. Sinkevich, L.G. Dezhenkova, D.N. Kaluzhny, N.S. Ilyinsky, V.I. Borshchevskiy, D. Schols, A.E. Shchekotikhin, Synthesis and antitumor activity of cyclopentane-fused anthraquinone derivatives, European Journal of Medicinal Chemistry, 2024, 265, 116103, https://doi.org/10.1016/j.ejmech.2023.116103

26. M.I. Treshchalin, V.A. Polozkova, E.I. Moiseenko, A.E. Shchekotikhin, S.A. Dovzhenko, M.B. Kobrin, E.R. Pereverzeva, Experimental Evaluation of the Hypersensitivity Reactions of a New Glycopeptide Antibiotic Flavancin in Animal Models, Pharmaceuticals, 2023, 16(11), 1569; https://doi.org/10.3390/ph16111569

     

27. V.A. Litvinova, A.S. Gostev, A.S. Tikhomirov, A.E. Shchekotikhin, New heteroarene-fused anthraquinones: Synthesis and PyBOP-mediated amination, Tetrahedron, 2023, 149, 4, 133722, https://doi.org/https://doi.org/10.1016/j.tet.2023.133722

     

28. A. Islam, X.C. Chen, C.-W. Weng, C.-Y. Chen, C.-W. Wang, M.-K. Chen, A.S. Tikhomirov, A.E. Shchekotikhin, P.J. Chueh, Water-soluble 4-(dimethylaminomethyl)heliomycin exerts greater antitumor effects than parental heliomycin by targeting the tNOX-SIRT1 axis and apoptosis in oral cancer cells, eLife, 2023, https://doi.org/10.7554/eLife.87873.1

     

29. В.А. Литвинова, А.С. Тихомиров, Методы синтеза 1,3-оксазолидин-2-онов, Методы синтеза 1,3-оксазолидин-2-онов, Химия гетероциклических соединений, 2023, 59(11/12), 733-735

     

30. K. Shapovalova, G. Zatonsky, N. Grammatikova, I. Osterman, E. Razumova, A. Shchekotikhin, A. Tevyashova, Synthesis of 6”-Modified Kanamycin A Derivatives and Evaluation of Their Antibacterial Properties. Pharmaceutics, 2023, 15, 1177. https://doi.org/10.3390/pharmaceutics15041177

     

31. A.A. Panov, Quantum-Chemical Study of Keto-Enol Equilibrium and Global Electrophilicity of Hydroxymaleimide Derivatives. Doklady Physical Chemistry, 2023, 508, 28–32, https://doi.org/10.1134/S001250162360002X

     

32. Levshin I.B., Simonov A.Y., Lavrenov S.N., Panov A.A., Grammatikova N.E., Alexandrov A.I., Ghazy E.S.M.O., Savin N.A., Gorelkin P.V., Erofeev A.S., Polshakov V.I. Antifungal Thiazolidines: Synthesis and Biological Evaluation of Mycosidine Congeners. Pharmaceuticals, 2022, 15, 5, 563-586. DOI: 10.3390/ph15050563

     

33. Treshchalin M.I., Polozkova V.A., Moiseenko E.I., Treshalina H.M., Shchekotikhin A.E., Pereverzeva E.R. Evaluation of Toxic Properties of New Glycopeptide Flavancin on Rats. Pharmaceuticals, 2022, 15, 661. DOI: 10.3390/ph15060661

     

34. A.N. Tevyashova, S.S. Efimova, A.I. Alexandrov, E.S.M.O. Ghazy, E.N. Bychkova, S.E. Solovieva, G.B. Zatonsky, N.E. Grammatikova, L.G. Dezhenkova, E.R. Pereverzeva, E.B. Isakova, O.S. Ostroumova, O.A. Omelchuk, V.V. Muravieva, M.M. Krotova, T.V. Priputnevich, A.E. Shchekotikhin, Semisynthetic Amides of Polyene Antibiotic Natamycin, ACS Infectious Diseases 2022, 2022, https://doi.org/10.1021/acsinfecdis.2c00237

35. A. Tevyashova, S. Efimova, A. Alexandrov, O. Omelchuk, E. Ghazy, E. Bychkova, G. Zatonsky, N. Grammatikova, L. Dezhenkova, S. Solovieva, O. Ostroumova, A. Shchekotikhin, Semisynthetic Amides of Amphotericin B and Nystatin A1: A Comparative Study of In Vitro Activity/Toxicity Ratio in Relation to Selectivity to Ergosterol Membranes, Antibiotics 2023, 12(1), 151; https://doi.org/10.3390/antibiotics12010151