Department of microbiology

Organized in 1953 under the direction of G.F. Gause. Since 1986 the department was headed by Сorresponding Member of RAMS Yu.V. Dudnik. Since 2003 the head of the Department is Doctor of Biological Sciences, Honored Scientist of Russia, Professor Larissa Petrovna Terekhova The department includes:

Laboratory of taxonomic study and culture collection of microorganisms

Organized in 1965 under the leadership of Professor T.P. Preobrazhenskaya, at the present time Head of laboratory - Dr.Sci., Professor, Honored Scientist of the Russian Federation Larissa Petrovna Terekhova

Staff:

  • KULIKOVA Nina Georgievna, Ph.D., Researcher;
  • SINYOVA Olga Nikolaevna, Researcher;
  • IVANKOVA Tatyana Dmitrievna, Researcher;
  • Ustinova Elena Vladimirovna, Engineer;
  • UTKINA Ksenia Mihailovna, Engineer;
  • KURAKINA Elena Alekseevna, Engineer

The main areas of research:

  • Isolation of microorganisms from natural sources and investigation of their diversity.
  • Study of the biological activity of the isolated cultures and the initial selection of producers of biologically active substances, which are promising for further study.
  • Development of new methods for the isolation of actinomycetes, which promote the fullest detection of their diversity and the isolation of rare cultures.
  • Isolation of actinomycetes-endophytes from plant leaves.
  • Taxonomic studies of actinomycetes isolated from natural habitats.

Major achievements:

  • An effective system of primary identification of producers of known antibiotics has been created and is being used in practice.
  • Methods for isolating of actinomycetes from natural sources using chemical, physical and biological factors have been developed.
  • The original producers of a number of antibacterial and antitumor antibiotics, including clinically important antibiotics, such as gramicidin S, monomycin (paromomycin), colimycin (neomycin), albomycin, ristomycin, lincomycin, kanamycin, heliomycin, olivomycin, bruneiomycin (streptomigrin), rubomycin (daunorubicin ), carminomycin and bleomycetin (bleomycin).
  • New species of actinomycetes have been described and included in the Approved Lists of Bacterial Names.

    Scientific cooperation:

    • Lomonosov Moscow State University: Faculty of Biology, Faculty of Soil Science
    • Skryabin Institute of Biochemistry and Physiology of Microorganisms (IBPM RAS) (Pushchino, Moscow region)
    • A.N. Belozersky Research Institute of Physico-Chemical Biology MSU
    • Winogradsky Institute of Microbiology RAS

    Contact information: Tel. (499) 255-20-13; E-mail: terekhova@list.ru

    Sector of the Search for Natural Compounds overcoming the Resistance of Bacteria



    Organized in 1997. Head - Ph.D. EFREMENKOVA Olga Vladimirovna

    Staff:

    • Efremenkova OV, Ph.D., Head of the Sector
    • I. Malanicheva, Ph.D., Senior Researcher
    • Malkina ND, Ph.D., Researcher
    • Glukhova AA, Researcher
    • Efimenko TA, Researcher
    • Sumarukova IG, Researcher
    • Boykova Yu.V., Researcher
    • Vasilyeva B.F., Researcher
    • Dem'yankova MV, Senior Laboratory Assistant
    • Karabanova AA, Laboratory Assistant

    The main areas of research:

    • Research of antibiotic producers, overcoming the antibiotic resistance of microorganisms
    • Development of cultural collection of antibiotic producers
    • Design of specific and general methods for induction of antibiotic biosynthesis
    • Search for biologically active synthetic compounds to overcome the antibiotic resistance of microorganisms

    Major achievements:

    • Development of the scheme for the analysis of strains, allowing early selection of antibiotic producers, that overcome the resistance of microorganisms.
    • Identification of the main taxonomic and ecological groups of organisms, most promising for the search of producers of antibiotics.
    • The creation of collection of actinomycetes, fungi and eubacteria as producers of antibiotics (846 strains).
    • Development of the method to increase the level of biosynthesis of certain antibiotics produced by actinomycetes, using regulators of the A-factor group.
    • The production of two medicinal products (immunostimulant "OVO-D" and antitumor antibiotic mitomycin C) on the base of patented and introduced investigations.

    Scientific cooperation:

    • Winogradsky Institute of Microbiology RAS
    • Department of Mycology and Algology, Biological Faculty, Lomonosov Moscow State University (Moscow)
    • Institute of Bioorganic Chemistry. M.M. Shemyakin and Yu.A. Ovchinnikov Institute RAS (Moscow)
    • A.N. Belozersky Institute Of Physico-Chemical Biology Moscow State University (Moscow)
    • Federal State Budgetary Institution “Academician V.I.Shumakov Federal Research Center of Transplantology and Artificial Organs”, Ministry of Health of the Russian Federation
    • Engelhardt Institute of Molecular Biology RAS

    Contact information: Tel. (499) 255-7731; E-mail: ovefr@narod.ru Publications of the Sector of the Search for Natural Compounds Overcoming the Resistance of Bacteria is HERE





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